Impact of inclusion of a poor-quality embryo with a good-quality embryo on pregnancy outcomes in vitrified-warmed blastocyst transfers.
Reprod Biomed Online
; 49(3): 104104, 2024 09.
Article
de En
| MEDLINE
| ID: mdl-39032356
ABSTRACT
RESEARCH QUESTION Does the co-transfer of a good-quality embryo and a poor-quality embryo influence pregnancy outcomes in comparison to the transfer of a single good-quality embryo in vitrified-warmed blastocyst transfer cycles? DESIGN:
This retrospective cohort study involved a total of 11,738 women who underwent IVF/intracytoplasmic sperm injection cycles and vitrified-warmed blastocyst transfer at a tertiary-care academic medical from January 2015 to June 2022. The study population was categorized into two groups single-blastocyst transfer (SBT; participants who underwent single good-quality embryo transfer, nâ¯=â¯9338) versus double-blastocyst transfer (DBT; participants who underwent transfers with a poor and a good-quality embryo, nâ¯=â¯2400).RESULTS:
The live birth rate (LBR) was significantly higher in the DBT group in comparison with the SBT group (65.6% versus 56.3%, P < 0.001). Multivariable logistic regression analysis showed that DBT was an independent predictor for LBR with a strong potential impact (adjusted odds ratio 1.55, 95% confidence interval 1.41-1.71; P < 0.001). However, the multiple birth rate was significantly higher in the good-quality embryo and poor-quality embryo group compared with patients undergoing a single good-quality embryo transfer (41.4% versus 1.8%; P < 0.001).CONCLUSIONS:
In vitrified-warmed blastocyst transfer cycles, LBR was higher following DBT with one good-quality and one poor-quality embryo compared with SBT. However, this was at the expense of a marked increase in the likelihood of multiple gestations. Physicians should still balance the benefits and risks of double-embryo transfer.Mots clés
Texte intégral:
1
Collection:
01-internacional
Base de données:
MEDLINE
Sujet principal:
Issue de la grossesse
/
Transfert d'embryon
/
Vitrification
Limites:
Adult
/
Female
/
Humans
/
Pregnancy
Langue:
En
Journal:
Reprod Biomed Online
/
Reprod. biomed. online
/
Reproductive biomedicine online
Sujet du journal:
MEDICINA REPRODUTIVA
Année:
2024
Type de document:
Article
Pays d'affiliation:
Chine
Pays de publication:
Pays-Bas