A dispensable role of mural cell-derived laminin-α5 in intracerebral hemorrhage.
J Cereb Blood Flow Metab
; 44(9): 1677-1690, 2024 Sep.
Article
de En
| MEDLINE
| ID: mdl-39053486
ABSTRACT
Although most laminin isoforms are neuroprotective in stroke, mural cell-derived laminin-α5 plays a detrimental role in an ischemia-reperfusion model. To determine whether this deleterious effect is an intrinsic feature of mural cell-derived laminin-α5 or unique to ischemic stroke, we performed loss-of-function studies using middle-aged mice with laminin-α5 deficiency in mural cells (α5-PKO) in an intracerebral hemorrhage (ICH) model. Control and α5-PKO mice exhibited comparable changes in all parameters examined, including hematoma size, neuronal death, neurological function, blood-brain barrier integrity, and reactive gliosis. These findings highlight a minimal role of mural cell-derived laminin-α5 in ICH. Together with the detrimental role of mural cell-derived laminin-α5 in ischemic stroke, these negative results in ICH model suggest that mural cell-derived laminin-α5 may exert distinct functions in different diseases.
Mots clés
Texte intégral:
1
Collection:
01-internacional
Base de données:
MEDLINE
Sujet principal:
Barrière hémato-encéphalique
/
Hémorragie cérébrale
/
Laminine
Limites:
Animals
Langue:
En
Journal:
J Cereb Blood Flow Metab
/
J. cereb. blood flow metab
/
Journal of cerebral blood flow and metabolism
Année:
2024
Type de document:
Article
Pays d'affiliation:
États-Unis d'Amérique
Pays de publication:
États-Unis d'Amérique