"Boosting" tumor immunity in elderly mice by hyperactivating dendritic cells.

Liu, Jiaqi; Shao, Feng

Liu, Jiaqi; Shao, Feng.

Affiliation

Liu J; Graduate Program in Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, P.R. China; National Institute of Biological Sciences, Beijing, P.R. China.
Shao F; Graduate Program in Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, P.R. China; National Institute of Biological Sciences, Beijing, P.R. China; Tsinghua Institute of Multidisciplinary Biomedical Research, Tsinghua University, Beijing, P.R. China; New Cornerstone Science Laboratory, Shenzhen, P.R. China; Changping Laboratory, Beijing, P.R. China. Electronic address: shaofeng@nibs.ac.cn.

Cell ; 187(15): 3885-3887, 2024 Jul 25.

Article de En | MEDLINE | ID: mdl-39059365

ABSTRACT

ABSTRACT

Immunosenescence poses a significant challenge to tumor immunotherapy in elderly individuals. In this issue of Cell, Zhivaki et al. elucidate that dendritic cells "hyperactivated" by specific adjuvants elicit TH1-skewed CD4+ T cell responses in a manner contingent on the NLRP3 inflammasome, which can eliminate tumors in aged mice.

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Texte intégral: 1 Collection: 01-internacional Base de données: MEDLINE Sujet principal: Cellules dendritiques Limites: Animals / Humans Langue: En Journal: Cell Année: 2024 Type de document: Article Pays de publication: États-Unis d'Amérique

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