Aching to defend: spleen innervation drives humoral immunity.

Eichwald, Tuany; Talbot, Sebastien

Eichwald, Tuany; Talbot, Sebastien.

Affiliation

Eichwald T; Department of Biomedical and Molecular Sciences, Queen's University, Kingston, Ontario, Canada; Department of Physiology and Pharmacology, Karolinska Institutet, Solna, Sweden.
Talbot S; Department of Biomedical and Molecular Sciences, Queen's University, Kingston, Ontario, Canada; Department of Physiology and Pharmacology, Karolinska Institutet, Solna, Sweden. Electronic address: sebastien.talbot@ki.se.

Trends Immunol ; 45(8): 574-576, 2024 Aug.

Article de En | MEDLINE | ID: mdl-39060142

ABSTRACT

ABSTRACT

The immune and sensory nervous systems communicate to maintain homeostasis. Wu et al. recently demonstrated that sensory neurons innervate the mouse spleen. These neurons promote calcitonin gene-related peptide (CGRP)-dependent responses in splenic B cell germinal centers (GCs) and antigen-specific antibody production. Dietary capsaicin activates these neurons to enhance humoral immunity against influenza virus infection.

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Texte intégral: 1 Collection: 01-internacional Base de données: MEDLINE Sujet principal: Rate / Lymphocytes B / Centre germinatif / Immunité humorale Limites: Animals / Humans Langue: En Journal: Trends Immunol / Trends immunol / Trends in immunology Sujet du journal: ALERGIA E IMUNOLOGIA Année: 2024 Type de document: Article Pays d'affiliation: Suède Pays de publication: Royaume-Uni

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