PGC-1&#945; agonism induces fetal hemoglobin and exerts antisickling effects in sickle cell disease.

Sun, Yanan; Benmhammed, Hajar; Al Abdullatif, Salam; Habara, Alawi; Fu, Eric; Brady, Jordan; Williams, Christopher; Ilinski, Adrian; Sharma, Anusha; Mahdaviani, Kiana; Alekseyev, Yuriy O; Campbell, Joshua D; Steinberg, Martin H; Cui, Shuaiying

PGC-1α agonism induces fetal hemoglobin and exerts antisickling effects in sickle cell disease.

Sun, Yanan; Benmhammed, Hajar; Al Abdullatif, Salam; Habara, Alawi; Fu, Eric; Brady, Jordan; Williams, Christopher; Ilinski, Adrian; Sharma, Anusha; Mahdaviani, Kiana; Alekseyev, Yuriy O; Campbell, Joshua D; Steinberg, Martin H; Cui, Shuaiying.

Affiliation

Sun Y; Section of Hematology-Medical Oncology, Department of Medicine, Boston Medical Center, Boston University Chobanian & Avedisian School of Medicine, Boston, MA, USA.
Benmhammed H; Section of Hematology-Medical Oncology, Department of Medicine, Boston Medical Center, Boston University Chobanian & Avedisian School of Medicine, Boston, MA, USA.
Al Abdullatif S; Single Cell Sequencing Core Facility, Department of Medicine, Boston University Chobanian & Avedisian School of Medicine, Boston, MA, USA.
Habara A; Imam Abdulrahman Bin Faisal University, Department of Clinical Biochemistry, Dammam, Saudi Arabia.
Fu E; Sargent College of Health and Rehabilitation Sciences, Boston University, Boston, MA, USA.
Brady J; Sargent College of Health and Rehabilitation Sciences, Boston University, Boston, MA, USA.
Williams C; Single Cell Sequencing Core Facility, Department of Medicine, Boston University Chobanian & Avedisian School of Medicine, Boston, MA, USA.
Ilinski A; Section of Hematology-Medical Oncology, Department of Medicine, Boston Medical Center, Boston University Chobanian & Avedisian School of Medicine, Boston, MA, USA.
Sharma A; Section of Hematology-Medical Oncology, Department of Medicine, Boston Medical Center, Boston University Chobanian & Avedisian School of Medicine, Boston, MA, USA.
Mahdaviani K; Section of Hematology-Medical Oncology, Department of Medicine, Boston Medical Center, Boston University Chobanian & Avedisian School of Medicine, Boston, MA, USA.
Alekseyev YO; Department of Pathology and Laboratory Medicine, Boston University Chobanian & Avedisian School of Medicine, Boston, MA, USA.
Campbell JD; Division of Computational Biomedicine, Department of Medicine, Boston Medical Center, Boston University Chobanian & Avedisian School of Medicine, Boston, MA, USA.
Steinberg MH; Section of Hematology-Medical Oncology, Department of Medicine, Boston Medical Center, Boston University Chobanian & Avedisian School of Medicine, Boston, MA, USA.
Cui S; Section of Hematology-Medical Oncology, Department of Medicine, Boston Medical Center, Boston University Chobanian & Avedisian School of Medicine, Boston, MA, USA.

Sci Adv ; 10(31): eadn8750, 2024 Aug 02.

Article de En | MEDLINE | ID: mdl-39083598

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Texte intégral: 1 Collection: 01-internacional Base de données: MEDLINE Sujet principal: Hémoglobine foetale / Coactivateur 1-alpha du récepteur gamma activé par les proliférateurs de peroxysomes / Drépanocytose / Antidrépanocytaires Limites: Animals / Humans Langue: En Journal: Sci Adv Année: 2024 Type de document: Article Pays d'affiliation: États-Unis d'Amérique Pays de publication: États-Unis d'Amérique

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