Immune checkpoints and pancreatic beta cell dysfunction in HIV.
AIDS
; 38(11): 1725-1727, 2024 Sep 01.
Article
de En
| MEDLINE
| ID: mdl-39088830
ABSTRACT
We explored the impact of immune dysregulation on pancreatic beta cell injury in HIV patients. Analyzing 105 participant samples, we observed lower IL-21 levels and elevated immune checkpoint levels (e.g. PD-1, CD27+, CD40+) in untreated HIV patients. Notably, soluble TIM-3 correlated positively with improved beta cell function and inversely with beta cell stress, suggesting its potential role in beta cell protection in untreated HIV.
Texte intégral:
1
Collection:
01-internacional
Base de données:
MEDLINE
Sujet principal:
Infections à VIH
/
Cellules à insuline
Limites:
Adult
/
Female
/
Humans
/
Male
/
Middle aged
Langue:
En
Journal:
AIDS
Sujet du journal:
SINDROME DA IMUNODEFICIENCIA ADQUIRIDA (AIDS)
Année:
2024
Type de document:
Article
Pays d'affiliation:
États-Unis d'Amérique