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Maternal hypothyroidism and subsequent metabolic outcomes in children: a systematic review and meta-analysis.
Zhao, Lucy; Selvaratnam, Inthuja; Cunningham, Jessie; Filion, Kristian B; Grandi, Sonia M.
Affiliation
  • Zhao L; Faculty of Health Sciences, McMaster University, Hamilton, ON, Canada.
  • Selvaratnam I; Department of Child Health Evaluative Sciences, The Hospital for Sick Children, Peter Gilgan Centre for Research and Learning, Toronto, ON, Canada.
  • Cunningham J; Department of Child Health Evaluative Sciences, The Hospital for Sick Children, Peter Gilgan Centre for Research and Learning, Toronto, ON, Canada.
  • Filion KB; Department of Child Health Evaluative Sciences, The Hospital for Sick Children, Peter Gilgan Centre for Research and Learning, Toronto, ON, Canada.
  • Grandi SM; Centre for Clinical Epidemiology, Lady Davis Institute, Jewish General Hospital, Montreal, QC, Canada.
BMC Pediatr ; 24(1): 490, 2024 Aug 01.
Article de En | MEDLINE | ID: mdl-39090558
ABSTRACT

INTRODUCTION:

As the fetus relies on maternal thyroid hormones in early pregnancy, maternal hypothyroidism plays an important role in fetal development. However, the association between maternal hypothyroidism and metabolic disease in offspring is unclear.

OBJECTIVE:

To examine the association between maternal hypothyroidism in pregnancy and metabolic outcomes (obesity, hypertension, type 2 diabetes mellitus, and dyslipidemia) in children < 18 years.

METHODS:

We systematically searched 5 databases from inception to May 2023. Eligible studies included cohort, case-control, and randomized controlled trials involving children born to mothers with or without hypothyroidism in pregnancy. Data were pooled across studies using random-effects models for outcomes reported in at least three studies. Quality assessment was performed using the ROBINS-E tool for observational studies and the Cochrane Risk of Bias tool for trials.

RESULTS:

The search identified 3221 articles, of which 7 studies were included (1 trial, 6 observational). All studies were conducted outside of North America and ranged in size from 250 to > 1 million children. The follow-up time ranged from 6 to 20 years. Included studies support an increased risk of hypertension and glucose dysregulation in offspring exposed to maternal hypothyroidism (hypertension OR 1.08, 95% CI 0.75, 1.57 and HR 1.81, 95% CI 1.21, 2.69; diabetes RR 2.7, 95% CI 0.7, 10). In the pooled analysis, maternal hypothyroidism was not associated with obesity in offspring (OR 1.04, 95% CI 0.64, 1.70).

CONCLUSION:

This study found inconsistent evidence on the association between maternal hypothyroidism in pregnancy and metabolic outcomes in offspring, though associations with hypertension and glucose dysregulation are possible.
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Texte intégral: 1 Collection: 01-internacional Base de données: MEDLINE Sujet principal: Complications de la grossesse / Effets différés de l'exposition prénatale à des facteurs de risque / Hypothyroïdie Limites: Adolescent / Child / Female / Humans / Pregnancy Langue: En Journal: BMC Pediatr Sujet du journal: PEDIATRIA Année: 2024 Type de document: Article Pays d'affiliation: Canada Pays de publication: Royaume-Uni

Texte intégral: 1 Collection: 01-internacional Base de données: MEDLINE Sujet principal: Complications de la grossesse / Effets différés de l'exposition prénatale à des facteurs de risque / Hypothyroïdie Limites: Adolescent / Child / Female / Humans / Pregnancy Langue: En Journal: BMC Pediatr Sujet du journal: PEDIATRIA Année: 2024 Type de document: Article Pays d'affiliation: Canada Pays de publication: Royaume-Uni