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REPRODUCTIVE AGEING: BGP-15 mitigates adverse impacts of aging on sperm quality, fertility, and offspring health in male mice.
Gonzalez, Macarena B; Campugan, Carl A; Connaughton, Haley S; Andreas, Eryk; Winstanley, Yasmyn E; Williams, Elisha J; Dorian, Camilla L; Robertson, Sarah A; Shoubridge, Cheryl; Robker, Rebecca L.
Affiliation
  • Gonzalez MB; Robinson Research Institute, School of Biomedicine, The University of Adelaide, Adelaide, South Australia, Australia.
  • Campugan CA; Robinson Research Institute, School of Biomedicine, The University of Adelaide, Adelaide, South Australia, Australia.
  • Connaughton HS; Robinson Research Institute, School of Biomedicine, The University of Adelaide, Adelaide, South Australia, Australia.
  • Andreas E; Robinson Research Institute, School of Biomedicine, The University of Adelaide, Adelaide, South Australia, Australia.
  • Winstanley YE; Robinson Research Institute, School of Biomedicine, The University of Adelaide, Adelaide, South Australia, Australia.
  • Williams EJ; Robinson Research Institute, School of Biomedicine, The University of Adelaide, Adelaide, South Australia, Australia.
  • Dorian CL; Robinson Research Institute, School of Biomedicine, The University of Adelaide, Adelaide, South Australia, Australia.
  • Robertson SA; Robinson Research Institute, School of Biomedicine, The University of Adelaide, Adelaide, South Australia, Australia.
  • Shoubridge C; Robinson Research Institute, School of Biomedicine, The University of Adelaide, Adelaide, South Australia, Australia.
  • Robker RL; Robinson Research Institute, School of Biomedicine, The University of Adelaide, Adelaide, South Australia, Australia.
Reproduction ; 168(3)2024 09 01.
Article de En | MEDLINE | ID: mdl-39096934
ABSTRACT
In Brief Aging in men is associated with diminished sperm quality and a higher incidence of altered fetal development and miscarriage in resultant pregnancies. This study in mice identifies a therapeutic compound that, when administered to aged males, improves sperm quality, subsequent embryo development and post-natal offspring health. Abstract Aging in men is associated with diminished sperm quality and a higher incidence of altered fetal development and miscarriage in resultant pregnancies. We used a mouse model of advanced paternal age to characterize embryonic development in older male mice and tested whether pre-conception treatment with the mitochondrial activator BGP-15 improves reproductive outcomes in old males. Like older men, reproductively old male mice had higher levels of sperm DNA damage and delayed pre-implantation development, associated with a reduced fetal weight and placental weight. Analysis of neonatal outcomes of in vivo-conceived offspring found that pups sired by old males were smaller, had delayed locomotor development, and increased mortality. BGP-15 treatment for 5 days prior to conception reduced sperm DNA oxidation levels and improved on-time embryo development after IVF and pup survival. BGP-15 treatment for 3 weeks prior to conception improved on-time pre-implantation embryo development and fetal viability and increased fetal size in pregnancies sired by old males. These results validate that ageing negatively affects male fertility and offspring physiology and indicates that pre-conception treatment with BGP-15 has the potential to improve sperm quality as well as early embryo development and post-natal health.
Sujet(s)

Texte intégral: 1 Collection: 01-internacional Base de données: MEDLINE Sujet principal: Spermatozoïdes / Vieillissement / Fécondité Limites: Animals / Pregnancy Langue: En Journal: Reproduction / Reproduction (Cambridge) Sujet du journal: MEDICINA REPRODUTIVA Année: 2024 Type de document: Article Pays d'affiliation: Australie Pays de publication: Royaume-Uni

Texte intégral: 1 Collection: 01-internacional Base de données: MEDLINE Sujet principal: Spermatozoïdes / Vieillissement / Fécondité Limites: Animals / Pregnancy Langue: En Journal: Reproduction / Reproduction (Cambridge) Sujet du journal: MEDICINA REPRODUTIVA Année: 2024 Type de document: Article Pays d'affiliation: Australie Pays de publication: Royaume-Uni