Recent progresses in the cyclization and oxidation of polyketide biosynthesis.
Curr Opin Chem Biol
; 81: 102507, 2024 Aug.
Article
de En
| MEDLINE
| ID: mdl-39098210
ABSTRACT
Polyketides represent an important class of natural products, renowned for their intricate structures and diverse biological activities. In contrast to common fatty acids, polyketides possess relatively more rigid carbon skeletons, more complex ring systems, and chiral centers. These structural features are primarily achieved through distinctive enzymatic cyclizations and oxidations as tailoring steps. In this opinion, we discuss the recent progress in deciphering the mechanisms of cyclization and oxidation within polyketide biosynthesis. By shedding light on these enzymatic processes, this article seeks to motivate the community to unravel the remaining mysteries surrounding cyclase and oxidase functionalities and to explore novel polyketide natural products through genome mining.
Mots clés
Texte intégral:
1
Collection:
01-internacional
Base de données:
MEDLINE
Sujet principal:
Oxydoréduction
/
Polycétides
Langue:
En
Journal:
Curr Opin Chem Biol
Sujet du journal:
BIOQUIMICA
Année:
2024
Type de document:
Article