Adiponectin receptor agonist AdipoRon alleviates memory impairment in the hippocampus of septic mice.
Behav Brain Res
; 472: 115174, 2024 Aug 24.
Article
de En
| MEDLINE
| ID: mdl-39098398
ABSTRACT
Sepsis-associated encephalopathy (SAE) is a common and severe clinical feature of sepsis; however, therapeutic approaches are limited because of the unclear pathogenesis. Adiponectin receptor agonist (AdipoRon) is a small-molecule agonist of the adiponectin receptor that exhibits anti-inflammatory and memory-improving effects in various diseases. In the present study, we established lipopolysaccharide (LPS)-induced mice models of SAE and found that Adiponectin receptor 1 (AdipoR1) was significantly decreased in the hippocampus. Administration of AdipoRon improves memory impairment, mitigates synaptic damage, and alleviates neuronal death. Furthermore, AdipoRon reduces the number of microglia. More importantly, AdipoRon promotes the phosphorylation of adenosine 5 '-monophosphate activated protein kinase (pAMPK). In conclusion, AdipoRon is protective against SAE-induced memory decline and brain injury in the SAE models via activating the hippocampal adenosine 5 '-monophosphate activated protein kinase (AMPK).
Mots clés
Texte intégral:
1
Collection:
01-internacional
Base de données:
MEDLINE
Sujet principal:
Modèles animaux de maladie humaine
/
Récepteurs à l'adiponectine
/
Hippocampe
/
Troubles de la mémoire
Limites:
Animals
Langue:
En
Journal:
Behav Brain Res
Année:
2024
Type de document:
Article