Neuromicrobiology Comes of Age: The Multifaceted Interactions between the Microbiome and the Nervous System.
ACS Chem Neurosci
; 15(16): 2957-2965, 2024 Aug 21.
Article
de En
| MEDLINE
| ID: mdl-39102500
ABSTRACT
The past decade has seen an explosion in our knowledge about the interactions between gut microbiota, the central nervous system, and the immune system. The gut-brain axis has recently gained much attention due to its role in regulating host physiology. This review explores recent findings concerning potential pathways linking the gut-brain axis to the initiation, pathophysiology, and development of neurological disorders. Our objective of this work is to uncover causative factors and pinpoint particular pathways and therapeutic targets that may facilitate the translation of experimental animal research into practical applications for human patients. We highlight three distinct yet interrelated mechanisms (1) disruptions of both the intestinal and blood-brain barriers, (2) persistent neuroinflammation, and (3) the role of the vagus nerve.
Mots clés
Texte intégral:
1
Collection:
01-internacional
Base de données:
MEDLINE
Sujet principal:
Microbiome gastro-intestinal
/
Axe cerveau-intestin
Limites:
Animals
/
Humans
Langue:
En
Journal:
ACS Chem Neurosci
/
ACS chem. neurosci
/
ACS chemical neuroscience
Année:
2024
Type de document:
Article
Pays d'affiliation:
États-Unis d'Amérique
Pays de publication:
États-Unis d'Amérique