TGF-ß-induced lncRNA TBUR1 promotes EMT and metastasis in lung adenocarcinoma via hnRNPC-mediated GRB2 mRNA stabilization.
Cancer Lett
; 600: 217153, 2024 Sep 28.
Article
de En
| MEDLINE
| ID: mdl-39102940
ABSTRACT
The transforming growth factor-ß (TGF-ß) signaling pathway is pivotal in inducing epithelial-mesenchymal transition (EMT) and promoting cancer metastasis. Long non-coding RNAs (lncRNAs) have emerged as significant players in these processes, yet their precise mechanisms remain elusive. Here, we demonstrate that TGF-ß-upregulated lncRNA 1 (TBUR1) is significantly activated by TGF-ß via Smad3/4 signaling in lung adenocarcinoma (LUAD) cells. Functionally, TBUR1 triggers EMT, enhances LUAD cell migration and invasion in vitro, and promotes metastasis in nude mice. Mechanistically, TBUR1 interacts with heterogeneous nuclear ribonucleoprotein C (hnRNPC) to stabilize GRB2 mRNA in an m6A-dependent manner. Clinically, TBUR1 is upregulated in LUAD tissues and correlates with poor prognosis, highlighting its potential as a prognostic biomarker and therapeutic target for LUAD. Taken together, our findings underscore the crucial role of TBUR1 in mediating TGF-ß-induced EMT and metastasis in LUAD, providing insights for future therapeutic interventions.
Mots clés
Texte intégral:
1
Collection:
01-internacional
Base de données:
MEDLINE
Sujet principal:
Facteur de croissance transformant bêta
/
Protéine adaptatrice GRB2
/
Transition épithélio-mésenchymateuse
/
ARN long non codant
/
Adénocarcinome pulmonaire
/
Tumeurs du poumon
/
Souris nude
Limites:
Animals
/
Female
/
Humans
/
Male
Langue:
En
Journal:
Cancer Lett
Année:
2024
Type de document:
Article
Pays d'affiliation:
Chine
Pays de publication:
Irlande