Na+/H+-exchange inhibition by cariporide is compensated via Na+,HCO3--cotransport and has no net growth consequences for ErbB2-driven breast carcinomas.

Aaen, Pernille; Kristensen, Kristoffer B; Antony, Arththy; Hansen, Steen H; Cornett, Claus; Pedersen, Stine F; Boedtkjer, Ebbe

Na⁺/H⁺-exchange inhibition by cariporide is compensated via Na⁺,HCO₃^--cotransport and has no net growth consequences for ErbB2-driven breast carcinomas.

Aaen, Pernille; Kristensen, Kristoffer B; Antony, Arththy; Hansen, Steen H; Cornett, Claus; Pedersen, Stine F; Boedtkjer, Ebbe.

Affiliation

Aaen P; Department of Biomedicine, Aarhus University, Aarhus, Denmark.
Kristensen KB; Department of Biomedicine, Aarhus University, Aarhus, Denmark.
Antony A; Department of Biomedicine, Aarhus University, Aarhus, Denmark.
Hansen SH; Department of Pharmacy, University of Copenhagen, Copenhagen, Denmark.
Cornett C; Department of Pharmacy, University of Copenhagen, Copenhagen, Denmark.
Pedersen SF; Department of Biology, University of Copenhagen, Copenhagen, Denmark.
Boedtkjer E; Department of Biomedicine, Aarhus University, Aarhus, Denmark. Electronic address: eb@biomed.au.dk.

Biochim Biophys Acta Mol Basis Dis ; 1870(7): 167450, 2024 Oct.

Article de En | MEDLINE | ID: mdl-39111631

Sujet(s)
Mots clés

Breast cancer; Cariporide; ErbB2; HER2; Intracellular pH; NBCn1; NHE1; Slc4a7; Slc9a1

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Texte intégral: 1 Collection: 01-internacional Base de données: MEDLINE Sujet principal: Sulfones / Tumeurs du sein / Récepteur ErbB-2 / Prolifération cellulaire / Échangeur-1 de sodium-hydrogène / Guanidines Limites: Animals / Female / Humans Langue: En Journal: Biochim Biophys Acta Mol Basis Dis Année: 2024 Type de document: Article Pays d'affiliation: Danemark Pays de publication: Pays-Bas

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