Impact of neonatal sepsis on neurocognitive outcomes: a systematic review and meta-analysis.
BMC Pediatr
; 24(1): 505, 2024 Aug 07.
Article
de En
| MEDLINE
| ID: mdl-39112966
ABSTRACT
INTRODUCTION:
Sepsis is associated with neurocognitive impairment among preterm neonates but less is known about term neonates with sepsis. This systematic review and meta-analysis aims to provide an update of neurocognitive outcomes including cognitive delay, visual impairment, auditory impairment, and cerebral palsy, among neonates with sepsis.METHODS:
We performed a systematic review of PubMed, Embase, CENTRAL and Web of Science for eligible studies published between January 2011 and March 2023. We included case-control, cohort studies and cross-sectional studies. Case reports and articles not in English language were excluded. Using the adjusted estimates, we performed random effects model meta-analysis to evaluate the risk of developing neurocognitive impairment among neonates with sepsis.RESULTS:
Of 7,909 studies, 24 studies (n = 121,645) were included. Majority of studies were conducted in the United States (n = 7, 29.2%), and all studies were performed among neonates. 17 (70.8%) studies provided follow-up till 30 months. Sepsis was associated with increased risk of cognitive delay [adjusted odds ratio, aOR 1.14 (95% CI 1.01-1.28)], visual impairment [aOR 2.57 (95%CI 1.14- 5.82)], hearing impairment [aOR 1.70 (95% CI 1.02-2.81)] and cerebral palsy [aOR 2.48 (95% CI 1.03-5.99)].CONCLUSION:
Neonates surviving sepsis are at a higher risk of poorer neurodevelopment. Current evidence is limited by significant heterogeneity across studies, lack of data related to long-term neurodevelopmental outcomes and term infants.Mots clés
Texte intégral:
1
Collection:
01-internacional
Base de données:
MEDLINE
Sujet principal:
Sepsis néonatal
Limites:
Humans
/
Newborn
Langue:
En
Journal:
BMC Pediatr
Sujet du journal:
PEDIATRIA
Année:
2024
Type de document:
Article
Pays d'affiliation:
Singapour
Pays de publication:
Royaume-Uni