Criteria for Cytokine Storm Syndromes.
Adv Exp Med Biol
; 1448: 59-71, 2024.
Article
de En
| MEDLINE
| ID: mdl-39117808
ABSTRACT
In the past two decades, there has been a great deal of work aimed to devise diagnostic guidelines, classification criteria, and diagnostic scores for cytokine storm syndromes (CSSs). The most notable effort has been the large-scale multinational study that led to the development of the 2016 classification criteria for macrophage activation syndrome (MAS) complicating systemic juvenile idiopathic arthritis (JIA). Future studies should scrutinize the validity of the proposed criteria, particularly in systemic JIA patients treated with biologics, in children with subtle or incomplete forms of MAS, and in patients with MAS complicating other rheumatologic disorders. More generic CSS criteria are also available but often lack sensitivity and specificity in a wide variety of patient populations and CSSs of different etiologies. The coronavirus disease 2019 (COVID-19)-related lung disease led to an evolution of the concept of a "cytokine storm." Emerging and unsolved challenges in the diagnosis of the different forms of CSSs highlight the need for diagnostic tools and well-established classification criteria to enable timely recognition and correct classification of patients.
Mots clés
Adult-onset Still disease; COVID-19; COVID-19-associated cytokine storm; Classification criteria; Cytokine storm syndrome; Diagnostic guidelines; Diagnostic score; Hemophagocytic lymphohistiocytosis; Hemophagocytic syndromes; Histiocytosis; Kawasaki disease; MIS-C; Macrophage activation syndrome; Multisystem inflammatory syndrome in children; PIMS; Pediatric inflammatory multisystem syndrome; Systemic juvenile idiopathic arthritis; Systemic lupus erythematosus
Texte intégral:
1
Collection:
01-internacional
Base de données:
MEDLINE
Sujet principal:
Syndrome de libération de cytokines
/
COVID-19
Limites:
Child
/
Humans
Langue:
En
Journal:
Adv Exp Med Biol
Année:
2024
Type de document:
Article
Pays d'affiliation:
Italie
Pays de publication:
États-Unis d'Amérique