Probing the killing potency of tumor-infiltrating lymphocytes on microarrayed colorectal cancer tumoroids.
NPJ Precis Oncol
; 8(1): 179, 2024 Aug 14.
Article
de En
| MEDLINE
| ID: mdl-39143103
ABSTRACT
Immunotherapy has emerged as a new standard of care for certain cancer patients with specific cellular and molecular makeups. However, there is still an unmet need for ex vivo models able to readily assess the effectiveness of immunotherapeutic treatments in a high-throughput and patient-specific manner. To address this issue, we have developed a microarrayed system of patient-derived tumoroids with recreated immune microenvironments that are optimized for the high-content evaluation of tumor-infiltrating lymphocyte functionality. Here we show that this system offers unprecedented opportunities to evaluate tumor immunogenicity, characterize the response to immunomodulators, and explore novel approaches for personalized immuno-oncology.
Texte intégral:
1
Collection:
01-internacional
Base de données:
MEDLINE
Langue:
En
Journal:
NPJ Precis Oncol
Année:
2024
Type de document:
Article
Pays d'affiliation:
Suisse
Pays de publication:
Royaume-Uni