Adherence to EAT-Lancet reference diet and risk of premature coronary artery diseases: a multi-center case-control study.
Eur J Nutr
; 2024 Aug 21.
Article
de En
| MEDLINE
| ID: mdl-39167176
ABSTRACT
BACKGROUND:
In 2019, a globally sustainable dietary pattern that primarily emphasizes the consumption of plant-based foods was proposed by the EAT-Lancet Commission. However, there is limited evidence regarding the association of this diet with coronary events.OBJECTIVES:
To determine the association between the EAT-Lancet Reference Diet (ELD) and premature coronary artery disease (PCAD) risk and its severity.METHODS:
This multi-center, case-control study was conducted within the framework of the Iran premature coronary artery disease (I-PAD). A total of 3185 participants aged under 70 years in women and 60 years in men were included. Cases were those whose coronary angiography showed stenosis ≥ 75% in at least one vessel or ≥ 50% in the left main artery (n = 2033), while the controls had normal angiography results (n = 1152). Dietary intake was assessed using a validated food frequency questionnaire. Logistic regression was utilized to examine the association between ELD and presence of PCAD.RESULTS:
Compared with individuals in the first quartile, those in the highest quartile of ELD (OR = 0.29, 95% CI 0.21, 0.39; P for trend < 0.001) and ELD calculated with minimum intake (OR = 0.39, 95% CI 0.29, 0.52; P < 0.001) had lower risk of PCAD. Individuals in the highest quartile of adherence to the ELD and ELD with minimum intake had 78% and 72% lower risk of having severe PCAD compared with those in the lowest quartile, respectively.CONCLUSION:
An inverse association was observed between adherence to the ELD and PCAD risk and its severity. Large-scale prospective cohort studies are required to confirm these findings.
Texte intégral:
1
Collection:
01-internacional
Base de données:
MEDLINE
Langue:
En
Journal:
Eur J Nutr
/
Eur. j. nutr
/
European journal of nutrition
Sujet du journal:
CIENCIAS DA NUTRICAO
Année:
2024
Type de document:
Article
Pays d'affiliation:
Iran
Pays de publication:
Allemagne