Anthracycline-induced cardiotoxicity: An overview from cellular structural perspective.
Biomed Pharmacother
; 179: 117312, 2024 Oct.
Article
de En
| MEDLINE
| ID: mdl-39167843
ABSTRACT
Anthracyclines are broad-spectrum anticancer drugs, but their clinical use is limited due to their severe cardiotoxicity. Anthracycline-induced cardiotoxicity (AIC) remains a significant cause of heart disease-related mortality in many cancer survivors. The underlying mechanisms of AIC have been explored over the past few decades. Reactive oxygen species and drug-induced inhibition of topoisomerase II beta are well-studied mechanisms, with mitochondria being a prominently investigated organelle. Emerging mechanisms such as ferroptosis, Ca2+ overload, autophagy and inflammation mediators have been implicated in recent years. In this review, our goal is to summarize and update the roles of various mechanisms in AIC, focusing on different cellular levels and further explore promising therapeutic approaches targeting these organelles or pathways.
Mots clés
Texte intégral:
1
Collection:
01-internacional
Base de données:
MEDLINE
Sujet principal:
Anthracyclines
/
Cardiotoxicité
Limites:
Animals
/
Humans
Langue:
En
Journal:
Biomed Pharmacother
Année:
2024
Type de document:
Article
Pays de publication:
France