The mark of success: The role of vaccine-induced skin scar formation for BCG and smallpox vaccine-associated clinical benefits.
Semin Immunopathol
; 46(5): 13, 2024 Aug 26.
Article
de En
| MEDLINE
| ID: mdl-39186134
ABSTRACT
Skin scar formation following Bacille Calmette-Guérin (BCG) or smallpox (Vaccinia) vaccination is an established marker of successful vaccination and 'vaccine take'. Potent pathogen-specific (tuberculosis; smallpox) and pathogen-agnostic (protection from diseases unrelated to the intentionally targeted pathogen) effects of BCG and smallpox vaccines hold significant translational potential. Yet despite their use for centuries, how scar formation occurs and how local skin-based events relate to systemic effects that allow these two vaccines to deliver powerful health promoting effects has not yet been determined. We review here what is known about the events occurring in the skin and place this knowledge in the context of the overall impact of these two vaccines on human health with a particular focus on maternal-child health.
Mots clés
Texte intégral:
1
Collection:
01-internacional
Base de données:
MEDLINE
Sujet principal:
Peau
/
Vaccin BCG
/
Vaccin antivariolique
/
Cicatrice
/
Vaccination
Limites:
Animals
/
Humans
Langue:
En
Journal:
Semin Immunopathol
Sujet du journal:
ALERGIA E IMUNOLOGIA
/
PATOLOGIA
Année:
2024
Type de document:
Article
Pays d'affiliation:
Danemark
Pays de publication:
Allemagne