Near infrared aggregation-induced emission fluorescent materials for lipid droplets testing and photodynamic therapy.
Luminescence
; 39(9): e4885, 2024 Sep.
Article
de En
| MEDLINE
| ID: mdl-39238366
ABSTRACT
Near-infrared (NIR) fluorescent probes with aggregation-induced emission (AIE) properties are of great significance in cell imaging and cancer therapy. However, the complexity of its synthesis, poor photostabilities, and expensive raw materials still pose some obstacles to their practical application. This study reported an AIE luminescent material with red emission and its application in in vitro imaging and photodynamic therapy (PDT) study. This material has the characteristics of simple synthesis, large Stokes shift, good photostabilities, and excellent lipid droplets-specific testing ability. Interestingly, this red-emitting material can effectively produce reactive oxygen species (ROS) under white light irradiation, further achieving PDT-mediated killing of cancer cells. In conclusion, this study demonstrates a simple approach to synthesize NIR AIE probes with both imaging and therapeutic effects, providing an ideal architecture for constructing long-wavelength emission AIE materials.
Mots clés
Texte intégral:
1
Collection:
01-internacional
Base de données:
MEDLINE
Sujet principal:
Photothérapie dynamique
/
Espèces réactives de l'oxygène
/
Gouttelettes lipidiques
/
Colorants fluorescents
/
Rayons infrarouges
Limites:
Humans
Langue:
En
Journal:
Luminescence
Sujet du journal:
BIOFISICA
/
BIOQUIMICA
Année:
2024
Type de document:
Article
Pays d'affiliation:
Chine
Pays de publication:
Royaume-Uni