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Age-Disturbed Vascular Extracellular Matrix Links to Abdominal Aortic Aneurysms.
Yu, Zhenping; Wu, Andong; Ke, Hao; Liu, Jiankun; Zhao, Ya; Zhu, Yuanzheng; Wang, Xiao-Yu; Xiang, Yang; Xin, Hong-Bo; Tian, Xiao-Li.
Affiliation
  • Yu Z; Institute of Translational Medicine, Nanchang University, Nanchang, Jiangxi, China.
  • Wu A; Aging and Vascular Diseases, Human Aging Research Institute (HARI), School of Life Science, Nanchang University, Nanchang, Jiangxi, China.
  • Ke H; Jiangxi Province Key Laboratory of Aging and Disease, Nanchang, Jiangxi, China.
  • Liu J; Cancer and Cell Senescence, Human Aging Research Institute (HARI), School of Life Science, Nanchang University, Nanchang, Jiangxi, China.
  • Zhao Y; Jiangxi Province Key Laboratory of Aging and Disease, Nanchang, Jiangxi, China.
  • Zhu Y; Aging and Vascular Diseases, Human Aging Research Institute (HARI), School of Life Science, Nanchang University, Nanchang, Jiangxi, China.
  • Wang XY; Jiangxi Province Key Laboratory of Aging and Disease, Nanchang, Jiangxi, China.
  • Xiang Y; Aging and Vascular Diseases, Human Aging Research Institute (HARI), School of Life Science, Nanchang University, Nanchang, Jiangxi, China.
  • Xin HB; Jiangxi Province Key Laboratory of Aging and Disease, Nanchang, Jiangxi, China.
  • Tian XL; Aging and Vascular Diseases, Human Aging Research Institute (HARI), School of Life Science, Nanchang University, Nanchang, Jiangxi, China.
J Gerontol A Biol Sci Med Sci ; 79(11)2024 Nov 01.
Article de En | MEDLINE | ID: mdl-39312673
ABSTRACT
Abdominal aortic aneurysm (AAA) is a common but life-threatening vascular condition in men at an advanced age. However, the underlying mechanisms of age-increased incidence and mortality of AAA remain elusive. Here, we performed RNA sequencing (RNA-seq) of mouse aortas from males (young 3-month, n = 4 vs old 23-month, n = 4) and integrated with the data sets of human aortas (young 20-39, n = 47 vs old 60-79 years, n = 92) from GTEx project and the data set (GSE183464) for AAA to search for age-shifted aortic aneurysm genes, their relevant biological processes, and signaling pathways. Angiotensin II-induced AAA in mice was used to verify the critical findings. We found 1 001 genes transcriptionally changed with ages in both mouse and human. Most age-increased genes were enriched intracellularly and the relevant biological processes included mitochondrial function and translational controls, whereas the age-decreased genes were largely localized in extracellular regions and cell periphery and the involved biological processes were associated with extracellular matrix (ECM). Fifty-one were known genes for AAA and found dominantly in extracellular region. The common age-shifted vascular genes and known aortic aneurysm genes had shared functional influences on ECM organization, apoptosis, and angiogenesis. Aorta with angiotensin II-induced AAA exhibited similar phenotypic changes in ECM to that in old mice. Together, we present a conserved transcriptional signature for aortic aging and provide evidence that mitochondrial dysfunction and the imbalanced ribosomal homeostasis act likely as driven-forces for aortic aging and age-disturbed ECM is the substrate for developing AAA.
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Texte intégral: 1 Collection: 01-internacional Base de données: MEDLINE Sujet principal: Vieillissement / Anévrysme de l'aorte abdominale / Matrice extracellulaire Limites: Adult / Aged / Animals / Humans / Male / Middle aged Langue: En Journal: J Gerontol A Biol Sci Med Sci Sujet du journal: GERIATRIA Année: 2024 Type de document: Article Pays d'affiliation: Chine Pays de publication: États-Unis d'Amérique

Texte intégral: 1 Collection: 01-internacional Base de données: MEDLINE Sujet principal: Vieillissement / Anévrysme de l'aorte abdominale / Matrice extracellulaire Limites: Adult / Aged / Animals / Humans / Male / Middle aged Langue: En Journal: J Gerontol A Biol Sci Med Sci Sujet du journal: GERIATRIA Année: 2024 Type de document: Article Pays d'affiliation: Chine Pays de publication: États-Unis d'Amérique