Evidence of obesity-induced inflammatory changes in client-owned cats.
Vet World
; 17(8): 1685-1692, 2024 Aug.
Article
de En
| MEDLINE
| ID: mdl-39328456
ABSTRACT
Background and Aim:
Insulin resistance and type 2 diabetes mellitus are common health issues in obese (OB) cats. In humans, obesity leads to alterations in adipokine and proinflammatory cytokine secretion, causing persistent inflammation. The inflammatory impact of obesity in cats remains unproven. This study investigated associations between obesity and inflammatory and metabolic changes in three groups of client-owned Brazilian domestic shorthair cats naturally lean, overweight (OW), and OB. Materials andMethods:
Cats from the Veterinary Hospital of Professor Sylvio Barbosa e Cardoso (FAVET/UECE) were clinically evaluated. Blood samples were collected for hematological and biochemical profile measurements, and part of the serum was used for measuring adipokine and inflammatory cytokines using sandwich enzyme-linked immunosorbent assay.Results:
In both the OW and OB groups, serum cholesterol and insulin concentrations increased, while triglyceride concentrations were notably elevated in the OB group. In the OW and OB groups, serum adiponectin, tumor necrosis factor-α, and interleukin-1ß levels were elevated, and leptin levels were significantly higher in the OB group.Conclusion:
This study is the first in Brazil to reveal increased serum levels of inflammatory markers in OW and OB client-owned felines. OW cats exhibited higher proinflammatory marker levels, implying obesity-induced inflammation.
Texte intégral:
1
Collection:
01-internacional
Base de données:
MEDLINE
Langue:
En
Journal:
Vet World
Année:
2024
Type de document:
Article
Pays d'affiliation:
Brésil
Pays de publication:
Inde