Synthesis of lysine-valinomycin by solid-phase segment condensation.
Int J Pept Protein Res
; 14(4): 356-63, 1979 Oct.
Article
de En
| MEDLINE
| ID: mdl-521217
ABSTRACT
In order to obtain a readily derivatized analog of the ionophore antibiotic valinomycin, [1-lysine] valinomycin (Lys-VAL) was synthesized. The compound was built up on a polystyrene support by stepwise segment condensation and was cyclized in solution. The segments used were didepsipeptides protected by the t-butyloxycarbonyl and p-nitrobenzyloxycarbonyl groups. Derivatives prepared by acylation of the epsilon-amino group of Lys-VAL included [14C]acetyl-Lys-VAL, dansyl-Lys-VAL, palmitoyl-Lys-VAL and dithiodiglycoyl-bis-Lys-VAL. These derivatives had a high potassium binding capacity but were in general much less active than VAL in mediating ion transport in membranes.
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Collection:
01-internacional
Base de données:
MEDLINE
Sujet principal:
Valinomycine
/
Ionophores
/
Lysine
Langue:
En
Journal:
Int J Pept Protein Res
Année:
1979
Type de document:
Article