Effect of aging on liver glutathione levels and hepatocellular injury from carbon tetrachloride, allyl alcohol or galactosamine.
Drug Chem Toxicol
; 7(6): 595-604, 1984.
Article
de En
| MEDLINE
| ID: mdl-6534734
ABSTRACT
Severity of liver damage 24 hr after i.p. administration of carbon tetrachloride (0.2 ml/kg), allyl alcohol (0.036 ml/kg) or galactosamine (400 mg/kg) was evaluated in male rats at 4-5, 14-15 or 24-25 months of age. Allyl alcohol hepatotoxicity, as judged by light microscopy and serum alanine aminotransferase levels, increased markedly as a function of age. In contrast, carbon tetrachloride and galactosamine toxicities were unchanged or slightly diminished in old rats. Hepatic glutathione (GSH) concentrations were unaffected by aging; thus, the age-dependent increase in susceptibility to allyl alcohol toxicity was not a result of diminished GSH availability in old age. Hepatotoxicant-induced changes in GSH were observed in allyl alcohol-treated old rats (20% increase) and in galactosamine-treated young-adult and middle-aged rats (30% decrease).
Recherche sur Google
Collection:
01-internacional
Base de données:
MEDLINE
Sujet principal:
Intoxication au tétrachlorure de carbone
/
Propanols
/
Lésions hépatiques dues aux substances
/
Galactosamine
/
Glutathion
/
Foie
Type d'étude:
Etiology_studies
Limites:
Animals
Langue:
En
Journal:
Drug Chem Toxicol
Année:
1984
Type de document:
Article