Conversion in vitro of urinary (+)-penicillamine to its major metabolites, PSSP and PSSC.
Br J Clin Pharmacol
; 15(6): 755-6, 1983 Jun.
Article
de En
| MEDLINE
| ID: mdl-6871074
ABSTRACT
To investigate the discrepancy between the apparent pharmacokinetic disposition of (+)-penicillamine in plasma and urine, the spontaneous degradation of (+)-penicillamine was studied in acidified and non-acidified urine. Degradation was prevented by acidification. The oxidized metabolites were converted to reduced (+)-penicillamine by electrolysis.
Texte intégral:
1
Collection:
01-internacional
Base de données:
MEDLINE
Sujet principal:
Pénicillamine
Limites:
Humans
/
Male
Langue:
En
Journal:
Br J Clin Pharmacol
Année:
1983
Type de document:
Article