Possible dual role of anti-idiotypic antibodies in combined passive and active immunotherapy in honeybee sting allergy.
J Allergy Clin Immunol
; 93(6): 1039-46, 1994 Jun.
Article
de En
| MEDLINE
| ID: mdl-7516355
ABSTRACT
BACKGROUND:
Passive infusion of beekeepers' plasma was shown to protect patients against systemic reactions occurring during active immunotherapy by mechanisms still to be clarified. It is tempting to speculate that anti-idiotypic antibodies could play a role because they are found in beekeepers' plasma and are involved in the regulation of IgE synthesis.METHODS:
In this report we studied the effects of passive infusion of a beekeeper's plasma rich in anti-idiotypic antibodies to a patient who experienced systemic reactions to honeybee venom.RESULTS:
We reported, during the days after the infusion, a decrease of clinical sensitivity to the honeybee venom. Indeed, the patient tolerated a cumulative dose of 280 micrograms of venom without adverse reactions. We also observed decreases in skin mast cell and in basophil sensitivity. After the plasma infusion, a modified rush immunotherapy with honeybee venom was initiated in our patient. In the following 76 weeks, increased levels of anti-idiotypic antibodies in the serum of the patient were associated with a diminution of specific antibodies (IgG and IgE) to honeybee venom.CONCLUSION:
These results suggest a dual role of anti-id in our combined protocol of passive and active immunotherapy an immediate action on clinical sensitivity along with a decrease of skin mast cell and basophil sensitivity and an immunoregulatory role on specific antibody production.
Recherche sur Google
Collection:
01-internacional
Base de données:
MEDLINE
Sujet principal:
Venins d'abeille
/
Anticorps anti-idiotypiques
/
Immunisation passive
/
Vaccination
/
Morsures et piqûres d'insectes
Type d'étude:
Guideline
Limites:
Adult
/
Female
/
Humans
Langue:
En
Journal:
J Allergy Clin Immunol
Année:
1994
Type de document:
Article
Pays d'affiliation:
Canada