Noradrenaline and potentiation in the chick brain slice.
Neuroreport
; 6(11): 1501-4, 1995 Jul 31.
Article
de En
| MEDLINE
| ID: mdl-7579134
ABSTRACT
The role of the noradrenergic system as a modulator of neurotransmission in the chick forebrain was investigated in brain slices containing the medial hyperstriatum ventrale, an area known to be involved in learning and memory. The alpha 2-agonist clonidine (20 microM) decreased the post-synaptic response to local stimulation at 0.1 Hz, while activation of beta 2 receptors increased this response. Induction of persistent potentiation following stimulation at 5 Hz was blocked by drugs (20 microM ICI 118,551; 20 microM propranolol) which showed preferential antagonistic activity at the beta 2 receptor but not by the beta 1-preferential antagonist timolol. This effect may be due to an interaction with the NMDA receptor system.
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Collection:
01-internacional
Base de données:
MEDLINE
Sujet principal:
Norépinéphrine
/
Prosencéphale
/
Potentialisation à long terme
/
Agonistes des récepteurs alpha-2 adrénergiques
Limites:
Animals
Langue:
En
Journal:
Neuroreport
Sujet du journal:
NEUROLOGIA
Année:
1995
Type de document:
Article
Pays d'affiliation:
Royaume-Uni