Strong adjuvant action of Klebsiella O3 lipopolysaccharide and its inhibition of systemic anaphylaxis.
FEMS Immunol Med Microbiol
; 10(3-4): 181-4, 1995 Feb.
Article
de En
| MEDLINE
| ID: mdl-7773234
ABSTRACT
Immunization with lipopolysaccharide from Klebsiella O3 as an immunological adjuvant did not cause the death of mice in systemic anaphylaxis to bovine serum albumin. On the other hand, most mice immunized with lipopolysaccharide from Escherichia coli O111, Klebsiella O4 and Salmonella minnesota did die. Klebsiella O3 lipopolysaccharide enhanced IgM and IgG antibody response to BSA more markedly than Escherichia coli O111 lipopolysaccharide, while it affected the production of IgE antibody only slightly. therefore, it is suggested that the inhibition of systemic anaphylaxis by Klebsiella O3 lipopolysaccharide adjuvant might be related to its strong adjuvant action on IgM and IgG class antibody production, and that high levels of circulating IgM and IgG antibodies might act as blocking antibodies in the development of IgE-mediated systemic anaphylaxis.
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Collection:
01-internacional
Base de données:
MEDLINE
Sujet principal:
Adjuvants immunologiques
/
Lipopolysaccharides
/
Immunisation
/
Anaphylaxie
/
Klebsiella
Type d'étude:
Etiology_studies
Limites:
Animals
Langue:
En
Journal:
FEMS Immunol Med Microbiol
Sujet du journal:
ALERGIA E IMUNOLOGIA
/
DOENCAS TRANSMISSIVEIS
/
MICROBIOLOGIA
Année:
1995
Type de document:
Article
Pays d'affiliation:
Japon