Interaction of the high-affinity inhibitor tetrahydro-dUMP with the allosteric enzyme deoxycytidylate aminohydrolase.
Arch Biochem Biophys
; 310(1): 49-53, 1994 Apr.
Article
de En
| MEDLINE
| ID: mdl-8161220
ABSTRACT
Tetrahydro-dUMP, an analog of the putative transition state in aminohydrolysis of deoxycytidine monophosphate (dCMP) inhibits the allosteric enzyme deoxycytidylate aminohydrolase with high affinity. The inhibition is reversible, and its kinetics is consistent with the analog binding at the substrate site only to one and the same conformation that binds the substrate dCMP. Such kinetics is what would be expected for a transition state analog interacting in an allosteric "K system."
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Collection:
01-internacional
Base de données:
MEDLINE
Sujet principal:
DCMP deaminase
/
Nucléotides désoxyuridyliques
Limites:
Animals
Langue:
En
Journal:
Arch Biochem Biophys
Année:
1994
Type de document:
Article
Pays d'affiliation:
Italie