[Effects of 6-(alpha alpha-diphenylacetylpiperazinyl) phenyl-5-methyl-4,5-dihydro-3 (2H)-pyridazinone on rabbit platelet aggregation and TXB2, cAMP production].
Yao Xue Xue Bao
; 28(4): 256-9, 1993.
Article
de Zh
| MEDLINE
| ID: mdl-8213167
ABSTRACT
6-(alpha alpha-diphenylacetylpiperazinyl) phenyl-5-methyl-4,5-dihydro-3 (2H)-pyridazinone (DMDP) is a new synthetic pyridazinone derivative. This compound was shown to inhibit AA, ADP and PAF-induced rabbit platelet aggregation, and its IC50s were found to be 1.12 +/- 0.1, 4.19 +/- 0.5 and 2.97 +/- 0.1 mumol/L, respectively. At the concentration range of 1-500 mumol/L, the compound was found to depress TXB2 content and to increase cAMP levels in washed rabbit platelets in a dose-dependent manner. These might be the mechanisms of the compound on the inhibition of rabbit platelets.
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Collection:
01-internacional
Base de données:
MEDLINE
Sujet principal:
Pipérazines
/
Pyridazines
/
Thromboxane B2
/
Antiagrégants plaquettaires
/
Agrégation plaquettaire
/
AMP cyclique
Limites:
Animals
Langue:
Zh
Journal:
Yao Xue Xue Bao
Année:
1993
Type de document:
Article