Differential effect of ACTH1-24 and alpha-MSH induced grooming in the paraventricular nucleus of the hypothalamus.
Brain Res
; 603(2): 296-301, 1993 Feb 19.
Article
de En
| MEDLINE
| ID: mdl-8384922
ABSTRACT
Injection of ACTH1-24 as well as alpha-MSH in the paraventricular nucleus of the hypothalamus (PVH) induces intense grooming in the rat. While comparing the details of MSH, ACTH and control grooming, we found that the induction of grooming was highly site specific. Even injection of saline in that specific area produced some grooming, possibly due to the release of endogenous substances. To distinguish between effects caused by the peptides and the effects caused by the injection procedure, we compared the behavioural effects of saline and peptide injections in sites with exactly the same location in the PVH, in a post-hoc matched pairs design. Using this design we found that the grooming response induced by saline is of a limited duration. ACTH1-24 and alpha-MSH prolong grooming beyond that period. Interestingly, rats receiving alpha-MSH continued to groom, while rats receiving ACTH1-24 changed to scratching. This confirms earlier findings suggesting that grooming and scratching have a differential organization at the level of the PVH. Whether the peptides also have a role in the initiation of the grooming response, or just prolong a response caused by other local factors requires another experimental approach.
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Collection:
01-internacional
Base de données:
MEDLINE
Sujet principal:
Noyau paraventriculaire de l'hypothalamus
/
Hormone mélanotrope alpha
/
Tétracosactide
/
Soins du pelage
Limites:
Animals
Langue:
En
Journal:
Brain Res
Année:
1993
Type de document:
Article
Pays d'affiliation:
Pays-Bas