Use of synthetic prostaglandin E1 (misoprostol) for prevention of aspirin-induced gastroduodenal ulceration in arthritic dogs.
J Am Vet Med Assoc
; 202(2): 251-6, 1993 Jan 15.
Article
de En
| MEDLINE
| ID: mdl-8428830
ABSTRACT
A randomized, double-blind, controlled study was performed with 18 arthritic dogs administered aspirin (25 mg/kg of body weight, PO, q 8 h) and excipient (control group) or aspirin and misoprostol (100 micrograms, PO, q 8 h). Dogs in the misoprostol (n = 10) and control (n = 8) groups were primarily compared by use of sequential gastroduodenoscopy, changes in PCV, and prevalence of clinical signs of gastrointestinal disturbance over a 14-day treatment period. The misoprostol/aspirin-treated group had significantly (P < 0.05) less gastroduodenal hemorrhage and ulceration and a significantly (P < 0.05) lower prevalence of vomiting than did the control group.
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Collection:
01-internacional
Base de données:
MEDLINE
Sujet principal:
Arthrose
/
Ulcère peptique
/
Acide acétylsalicylique
/
Misoprostol
/
Maladies des chiens
Type d'étude:
Risk_factors_studies
Limites:
Animals
Langue:
En
Journal:
J Am Vet Med Assoc
Année:
1993
Type de document:
Article