[The role of vascular nitric oxide (NO) in the pathomechanism of pre-eclampsia]. / A vascularis nitrogén-oxid (NO) szerepe a praeeclampsia patomechanizmusában.

ABSTRACT

The significance of nitric-oxide as a biological mediator is increasingly elucidated in various physiological processes. In addition to the endothelium dependent vasodilator effect it also plays an important role as a neurotransmitter. Possible synthesis of endothelial nitric-oxide is an essential factor in the regulation of blood pressure and utero-placental circulation. Recently the relationship of nitric-oxide and preeclampsia has extensively been studied. The results of human studies and animal experiments suggest that insufficient production of endothelial nitric-oxide probably has an important role in the pathomechanism of preeclampsia.