A correlation between HLA-C matching and donor antirecipient CTL precursor frequency in bone marrow transplantation.
Transplantation
; 61(9): 1420-3, 1996 May 15.
Article
de En
| MEDLINE
| ID: mdl-8629311
ABSTRACT
A newly developed, reliable, DNA-based method for typing for alleles of the HLA-C locus has been applied in the context of unrelated, volunteer donors for bone marrow transplantation. Some donors matched for HLA-A, -B, -DR, and -DQ have been found to generate in vitro high frequencies of CTL reactive with the recipient's cells. Here we demonstrate that there is a highly significant correlation of the frequencies of CTL precursors and incompatibility at the HLA-C locus. These data indicate that HLA-C locus incompatibility should be avoided in unrelated donor bone marrow transplantation.
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Collection:
01-internacional
Base de données:
MEDLINE
Sujet principal:
Antigènes HLA-C
/
Transplantation de moelle osseuse
Limites:
Humans
Langue:
En
Journal:
Transplantation
Année:
1996
Type de document:
Article
Pays d'affiliation:
Royaume-Uni