DNA double-strand break repair functions defend against parvovirus infection.
J Virol
; 70(9): 6446-9, 1996 Sep.
Article
de En
| MEDLINE
| ID: mdl-8709279
ABSTRACT
We measured parvovirus replication and sensitivity to X-ray damage in nine CHO cell lines representing a variety of DNA repair deficiencies. We found that parvovirus replication efficiency increases with radiosensitivity. Parvovirus replication is disrupted at an early stage of infection in DNA repair-proficient cells, before conversion of the single-stranded viral DNA genome into the double-stranded replicative form. Thus, status of the DNA repair machinery inversely correlates with parvovirus replication and is proportional to the host's ability to repair X-ray-induced damage.
Texte intégral:
1
Collection:
01-internacional
Base de données:
MEDLINE
Sujet principal:
Récepteurs viraux
/
Réplication virale
/
Survie cellulaire
/
Parvovirus
/
Réparation de l'ADN
Limites:
Animals
Langue:
En
Journal:
J Virol
Année:
1996
Type de document:
Article
Pays d'affiliation:
États-Unis d'Amérique