Selective inhibitors of plasma kallikrein.
Immunopharmacology
; 32(1-3): 115-6, 1996 May.
Article
de En
| MEDLINE
| ID: mdl-8796284
ABSTRACT
Based on a tetrapeptide fragment [Pro387-Ser390] of HK we have developed a series of potent low molecular weight (5-600 Da) inhibitors of PK which are stable to the enzyme. These inhibitors show good selectivity for PK versus tissue kallikrein, thrombin and plasmin. Such inhibitors will help define the role of PK and kinins in human physiology and pathophysiology. They may also find clinical use in the treatment of diseases where kinins are important mediators.
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Collection:
01-internacional
Base de données:
MEDLINE
Sujet principal:
Kallicréines
/
Antienzymes
Limites:
Humans
Langue:
En
Journal:
Immunopharmacology
Année:
1996
Type de document:
Article
Pays d'affiliation:
Royaume-Uni