Structural and mechanistic relationships between nucleic acid polymerases.
Trends Biochem Sci
; 21(5): 186-90, 1996 May.
Article
de En
| MEDLINE
| ID: mdl-8871404
ABSTRACT
A superfamily of nucleic acid polymerases that includes the pol I and pol alpha classes of DNA-directed DNA polymerases, mitochondrial and phage DNA-directed RNA polymerases, and most RNA-directed polymerases may be defined on the basis of the occurrence of conserved sequence motifs and tertiary structure similarities between HIV-1 reverse transcriptase, DNA polymerase I and T7 RNA polymerase. Although sequence or structural similarities do not yet justify inclusion of the multi-subunit DNA-directed RNA polymerases in this superfamily, mechanistic similarities suggest a deep relationship between these and the simpler T7-like RNA polymerases.
Recherche sur Google
Collection:
01-internacional
Base de données:
MEDLINE
Sujet principal:
DNA-directed RNA polymerases
/
Structure tertiaire des protéines
/
DNA-directed DNA polymerase
Langue:
En
Journal:
Trends Biochem Sci
Année:
1996
Type de document:
Article
Pays d'affiliation:
États-Unis d'Amérique