Investigation of anti-inflammatory and antinociceptive activities of trans-dehydrocrotonin, a 19-nor-clerodane diterpene from Croton cajucara. Part 1.
Planta Med
; 62(5): 402-4, 1996 Oct.
Article
de En
| MEDLINE
| ID: mdl-8923802
ABSTRACT
The anti-inflammatory and antinociceptive effects of trans-dehydrocrotonin, isolated from the bark of Croton cajucara (Euphorbiaceae), were investigated using several animal models. The trans-dehydrocrotonin produced a significant inhibition of carrageenin-induced paw edema and cotton pellet granuloma in rats. It also inhibited the writhings in mice induced by acetic acid, but did not show a significant effect in the hot-plate test in mice. The LD50 of t-DCTN was 555.0 mg/kg (p.o.) for mice.
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Collection:
01-internacional
Base de données:
MEDLINE
Sujet principal:
Plantes médicinales
/
Anti-inflammatoires non stéroïdiens
/
Diterpènes de type clérodane
/
Diterpènes
/
Analgésiques
Limites:
Animals
Pays/Région comme sujet:
America do sul
/
Brasil
Langue:
En
Journal:
Planta Med
Année:
1996
Type de document:
Article
Pays d'affiliation:
Brésil