Islet cell and glutamic acid decarboxylase antibodies and heat-shock protein 65 responses in children with newly diagnosed insulin-dependent diabetes mellitus.
Immunol Lett
; 49(1-2): 123-6, 1996 Jan.
Article
de En
| MEDLINE
| ID: mdl-8964599
ABSTRACT
Islet cell antibodies (ICA) were detected in 66% and glutamic acid decarboxylase (GAD) antibodies in 64% of children (n = 47) with newly diagnosed insulin-dependent diabetes mellitus (IDDM). Fifteen percent of the patients had neither GAD nor ICA antibodies. Responses to mycobacterial heat-shock protein 65 (Hsp65) were detected in all patients. There was a significant correlation between anti-GAD antibodies and proliferation of peripheral blood mononuclear cells to Hsp65, and between ICA and antibodies to Hsp65.
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Collection:
01-internacional
Base de données:
MEDLINE
Sujet principal:
Autoanticorps
/
Protéines bactériennes
/
Chaperonines
/
Diabète de type 1
/
Glutamate decarboxylase
/
Alloanticorps
/
Anticorps antibactériens
Type d'étude:
Diagnostic_studies
Limites:
Adolescent
/
Child
/
Child, preschool
/
Humans
/
Infant
Langue:
En
Journal:
Immunol Lett
Année:
1996
Type de document:
Article
Pays d'affiliation:
Finlande