Marked reduction of mouse peritoneal CD5+ B cells by intraperitoneal administration of lipopolysaccharide.
Infect Immun
; 65(1): 122-6, 1997 Jan.
Article
de En
| MEDLINE
| ID: mdl-8975901
ABSTRACT
Intraperitoneal administration of lipopolysaccharide to mice induced a marked reduction of CD5+ B cells in the peritoneal cavity. The reduction was not induced by intravenous, subcutaneous, or oral administration of lipopolysaccharide. The reduction continued for about 10 days after the injection, and the CD5+ B-cell count recovered to the normal state about 14 days after the injection. The reduction of peritoneal CD5+ B cells might be caused by apoptotic cell death. Injection of lipopolysaccharide did not result in production of antibody to lipopolysaccharide. On the other hand, intraperitoneal injection of heat-killed bacteria did not induce a reduction of peritoneal CD5+ B cells and elicited the definite production of antibody to lipopolysaccharide.
Texte intégral:
1
Collection:
01-internacional
Base de données:
MEDLINE
Sujet principal:
Cavité péritonéale
/
Lipopolysaccharides
/
Sous-populations de lymphocytes B
/
Antigènes CD5
/
Klebsiella pneumoniae
Limites:
Animals
Langue:
En
Journal:
Infect Immun
Année:
1997
Type de document:
Article
Pays d'affiliation:
Japon