Amphetamine sensitization enhances regional c-fos expression produced by conditioned fear.
Neuroscience
; 76(4): 1097-103, 1997 Feb.
Article
de En
| MEDLINE
| ID: mdl-9027869
ABSTRACT
Chronically administered amphetamine can result in a paranoid psychosis that can be re-induced in former amphetamine abusers by psychological stressors. In an attempt to investigate the neurobiological correlates of this phenomenon, the present study examined the effects of prior D-amphetamine sensitization on regional c-fos expression induced by a psychological stressor. Rats received intermittent footshock in a distinctive environment for 30 min/day for three days. Three days after the last fear conditioning session, the animals received injections of saline or D-amphetamine (4 mg/kg, i.p.) once every second day for 16 days (eight injections in total). After a 14-day drug abstinent period, the animals were placed in the fear conditioning apparatus but without footshock. The amphetamine sensitization procedure significantly enhanced the effects of conditioned fear on c-fos expression in several brain regions. These included the cingulate cortex area 3, agranular insular cortex (layers 2 and 3), claustrum, piriform cortex, the shell region of the nucleus accumbens, medial striatum, ventral lateral septum, and CA3 and polymorphic layer of the hippocampal formation. These results indicate that D-amphetamine sensitization can have long-lasting effects on the neural circuitries activated by conditioned stressors.
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Collection:
01-internacional
Base de données:
MEDLINE
Sujet principal:
Chimie du cerveau
/
Protéines proto-oncogènes c-fos
/
Dexamfétamine
/
Peur
/
Stimulants du système nerveux central
Limites:
Animals
Langue:
En
Journal:
Neuroscience
Année:
1997
Type de document:
Article
Pays d'affiliation:
Canada