Therapy-related chromosomal changes and cytogenetic heterogeneity in human gliomas.
J Neurooncol
; 32(1): 7-17, 1997 Mar.
Article
de En
| MEDLINE
| ID: mdl-9049858
ABSTRACT
The karyotypes of 18 primary 'untreated' gliomas, 6 recurrent gliomas treated with radiotherapy and/or chemotherapy and 2 gliomas before and after treatment are described, based on observations using standard cytogenetic techniques. In comparison to the untreated gliomas there were relatively consistent chromosome differences in the treated gliomas, including (1) deletions of the long arm of chromosome 7 with breakpoint at q22, possibly induced by alkylating agents, and (2) numerous single cell abnormalities or unrelated clones of structural abnormalities, presumably induced by radiotherapy.
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Collection:
01-internacional
Base de données:
MEDLINE
Sujet principal:
Tumeurs du cerveau
/
Chromosomes
/
Hétérogénéité génétique
/
Gliome
Limites:
Adolescent
/
Adult
/
Aged
/
Female
/
Humans
/
Male
/
Middle aged
Langue:
En
Journal:
J Neurooncol
Année:
1997
Type de document:
Article
Pays d'affiliation:
Canada