Expression of an immunomodulatory protein known as progesterone induced blocking factor (PIBF) does not correlate with first trimester spontaneous abortions in progesterone supplemented women.
Am J Reprod Immunol
; 37(4): 330-4, 1997 Apr.
Article
de En
| MEDLINE
| ID: mdl-9161642
ABSTRACT
PROBLEM:
An immunomodulatory protein known as the progesterone induced blocking factor (PIBF) has been found to positively correlate with early pregnancy beta human chorionic gonadotropin (B-hCG) levels. The study presented herein evaluated PIBF levels from conception to the end of the first trimester to determine if lower levels will correlate with first trimester spontaneous abortions (SAB).METHOD:
Progesterone induced blocking factor expression by lymphocytes measured using an immunocytochemistry method was compared in pregnant women with ongoing vs. failed pregnancies.RESULTS:
There were no differences in the proportion of women having lymphocytes expressing PIBF or in the median numbers when comparing ongoing vs. failed pregnancies. There was no B-hCG interval where failed pregnancies were found to have lower frequency of PIBF expressing lymphocytes.CONCLUSION:
Inadequate PIBF expression independent of low P levels does not appear to be an etiologic factor for first trimester SABs; thus measuring this protein in pregnant women lacks practical usefulness.
Recherche sur Google
Collection:
01-internacional
Base de données:
MEDLINE
Sujet principal:
Protéines de la grossesse
/
Progestérone
/
Avortement spontané
/
Adjuvants immunologiques
/
Facteurs suppresseurs immunologiques
Type d'étude:
Prognostic_studies
Limites:
Female
/
Humans
/
Pregnancy
Langue:
En
Journal:
Am J Reprod Immunol
Année:
1997
Type de document:
Article
Pays d'affiliation:
États-Unis d'Amérique