Accuracy of cholesterol measurements in Italian clinical laboratories. Joint project GISSI prevention--Italian Society of Clinical Biochemistry. SIBioC GISSI Prevenzione Group.
Eur J Clin Chem Clin Biochem
; 35(4): 311-5, 1997 Apr.
Article
de En
| MEDLINE
| ID: mdl-9166977
ABSTRACT
We report the results of an external quality assessment scheme for serum total cholesterol measurement involving about 100 Italian laboratories participating in an epidemiological study of post myocardial infarction. Two frozen human serum pools with Abell-Kendall assigned values are distributed quarterly at the laboratories (up to now seven events occurred); the obtained results are evaluated and discussed. In one exercise (# 5) duplicated measurements were repeated on three different days. Eighty-five to 98% of the laboratories obtained results within the total error limits (+/- 8.9%). But, while precision (calculated on the six replicates of exercise # 5) is good (90% of the laboratories obtained CV < 3%), inaccuracy problems are evident in every event. Indeed the mean bias from the reference method value ranged from 1.54 and 3.49% in the various events.
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Collection:
01-internacional
Base de données:
MEDLINE
Sujet principal:
Chimie clinique
/
Cholestérol
Limites:
Humans
Pays/Région comme sujet:
Europa
Langue:
En
Journal:
Eur J Clin Chem Clin Biochem
Sujet du journal:
BIOQUIMICA
/
QUIMICA CLINICA
Année:
1997
Type de document:
Article
Pays d'affiliation:
Italie