Molecular analyses of human immunodeficiency virus type 1 V3 region quasispecies derived from plasma and peripheral blood mononuclear cells of the first long-term-nonprogressing mother and child pair.
J Infect Dis
; 175(6): 1510-5, 1997 Jun.
Article
de En
| MEDLINE
| ID: mdl-9180196
ABSTRACT
Molecular analyses were done for the V3 region quasispecies of human immunodeficiency virus type 1 (HIV-1) strains from plasma and peripheral blood mononuclear cells of the first HIV-1-infected long-term-nonprogressing mother-child pair whose members have survived for >13 years with stable CD4 T cell counts. There was a predominance of lower V3 loop charge and the absence of genotypic changes that are critical in phenotypic determination and tropism during HIV-1 infection. The intrahost genetic diversity between HIV-1 strains from the mother-child pair compared with HIV-1 strains from slow and rapid progressors suggested that a high genetic heterogeneity in HIV-1 strains from this HIV-1-infected long-term-nonprogressing mother and child pair was directly proportional to the length of their immunocompetent period.
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Collection:
01-internacional
Base de données:
MEDLINE
Sujet principal:
Fragments peptidiques
/
Variation génétique
/
Protéine d'enveloppe gp120 du VIH
/
Infections à VIH
/
VIH-1 (Virus de l'Immunodéficience Humaine de type 1)
Limites:
Female
/
Humans
/
Newborn
Langue:
En
Journal:
J Infect Dis
Année:
1997
Type de document:
Article
Pays d'affiliation:
Australie