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Nasal lesions induced by intranasal administration of benzaikonium chloride in rats.
Kuboyama, Y; Suzuki, K; Hara, T.
Affiliation
  • Kuboyama Y; Toxicological Research Laboratories, Kyowa Hakko Kogyo Co., Ltd., Yamaguchi, Japan.
J Toxicol Sci ; 22(2): 153-60, 1997 May.
Article de En | MEDLINE | ID: mdl-9198012
ABSTRACT
We investigated the lesions of nasal cavity mucous membrane caused by administration of 0.01, 0.05 and 0.10 w/v% Benzalkonium chloride (BZC) solutions in the nasal cavity of rats. No BZC-induced symptoms or nasal lesions were seen in the 0.01 w/v% BZC-treated group. On the other hand, BZC-induced symptoms such as nasal sound and rubbing the nose with forelegs were observed in the 0.05 and 0.10 w/v% BZC-treated groups. Additionally, BZC-induced lesions, including epithelial desquamation, inflammation and edema, occurred in the anterior nasal cavity in the 0.05 and 0.10 w/v% BZC-treated groups, but these lesions were confined to the dorsal meatus and the adjacent nasal septum. These results indicate that 0.01 w/v% BZC solution has no effect on the nasal cavity mucous membrane. However, 0.05 and 0.10 w/v% BZC solutions induce lesions in the nasal cavity mucous membrane due to their irritating effect.
Sujet(s)
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Collection: 01-internacional Base de données: MEDLINE Sujet principal: Conservateurs pharmaceutiques / Composés de benzalkonium / Anti-infectieux locaux / Fosse nasale Limites: Animals Langue: En Journal: J Toxicol Sci Année: 1997 Type de document: Article Pays d'affiliation: Japon
Recherche sur Google
Collection: 01-internacional Base de données: MEDLINE Sujet principal: Conservateurs pharmaceutiques / Composés de benzalkonium / Anti-infectieux locaux / Fosse nasale Limites: Animals Langue: En Journal: J Toxicol Sci Année: 1997 Type de document: Article Pays d'affiliation: Japon