Exportin 1 (Crm1p) is an essential nuclear export factor.
Cell
; 90(6): 1041-50, 1997 Sep 19.
Article
de En
| MEDLINE
| ID: mdl-9323132
ABSTRACT
Nuclear protein export is mediated by nuclear export signals (NESs), but the mechanisms governing this transport process are not well understood. Using a novel protein export assay in S. cerevisiae, we identify CRM1 as an essential mediator of nuclear protein export in yeast. Crm1p shows homology to importin beta-like transport factors and is able to specifically interact with both the NES motif and the Ran GTPase. A mutation in the shuttling protein Crm1p affects not only protein export, but also mRNA export, indicating that these pathways are tightly coupled in S. cerevisiae. The presented data are consistent with the conclusion that Crm1p is a carrier for the NES-mediated protein export pathway. We propose CRM1 be renamed exportin 1 (XPO1).
Recherche sur Google
Collection:
01-internacional
Base de données:
MEDLINE
Sujet principal:
Protéines fongiques
/
Protéines de transport
/
Noyau de la cellule
/
Récepteurs cytoplasmiques et nucléaires
Type d'étude:
Prognostic_studies
Langue:
En
Journal:
Cell
Année:
1997
Type de document:
Article
Pays d'affiliation:
États-Unis d'Amérique