Isolation and characterization of cDNAs corresponding to an additional member of the human histone deacetylase gene family.
J Biol Chem
; 272(44): 28001-7, 1997 Oct 31.
Article
de En
| MEDLINE
| ID: mdl-9346952
ABSTRACT
Several human cDNAs encoding a histone deacetylase protein, HDAC3, have been isolated. Analysis of the predicted amino acid sequence of HDAC3 revealed an open reading frame of 428 amino acids with a predicted molecular mass of 49 kDa. The HDAC3 protein is 50% identical in DNA sequence and 53% identical in protein sequence compared with the previously cloned human HDAC1. Comparison of the HDAC3 sequence with human HDAC2 also yielded similar results, with 51% identity in DNA sequence and 52% identity in protein sequence. The expressed HDAC3 protein is functionally active because it possesses histone deacetylase activity, represses transcription when tethered to a promoter, and binds transcription factor YY1. Similar to HDAC1 and HDAC2, HDAC3 is ubiquitously expressed in many different cell types.
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Collection:
01-internacional
Base de données:
MEDLINE
Sujet principal:
Famille multigénique
/
Histone deacetylases
Type d'étude:
Prognostic_studies
Limites:
Humans
Langue:
En
Journal:
J Biol Chem
Année:
1997
Type de document:
Article
Pays d'affiliation:
États-Unis d'Amérique