Fc gamma RIIa polymorphism in systemic lupus erythematosus.
Ann Rheum Dis
; 56(12): 744-6, 1997 Dec.
Article
de En
| MEDLINE
| ID: mdl-9496155
ABSTRACT
OBJECTIVES:
Polymorphism of the phagocyte IgG receptor Fc gamma RIIa may modulate immune complex mediated inflammation, particularly when immune complexes contain IgG2. Previous studies suggest that this polymorphism may be an important risk factor for lupus nephritis. Fc gamma RIIa is biallelic, the alleles R and H each having a gene frequency of about 50%. Nephritis has been associated with an increased frequency of the R allele. The frequency of common Fc gamma RIIa alleles was examined in white subjects from the United Kingdom and Greek subjects with systemic lupus erythematosus (SLE) and healthy controls.METHODS:
Fc gamma RIIa genotyping was performed using a single step polymerase chain reaction technique, which differentiates the two major alleles, R and H. Two study populations were examined (a) white subjects from the United Kingdom 66 controls and 81 with SLE (19 of whom had renal disease) and (b) Greek 52 controls and 42 with SLE (19 with renal disease).RESULTS:
No significant relation was observed between Fc gamma RIIa genotype and susceptibility to SLE or SLE nephritis.CONCLUSIONS:
The Fc gamma RIIa R allele does not seem to be associated with SLE (with or without renal disease) in our United Kingdom white or Greek populations.
Texte intégral:
1
Collection:
01-internacional
Base de données:
MEDLINE
Sujet principal:
Polymorphisme génétique
/
Antigènes CD
/
Récepteurs du fragment Fc des IgG
/
Lupus érythémateux disséminé
Type d'étude:
Risk_factors_studies
Limites:
Humans
Pays/Région comme sujet:
Europa
Langue:
En
Journal:
Ann Rheum Dis
Année:
1997
Type de document:
Article