[Pill cycle disturbance in simultaneous use of itraconazole and oral contraceptives]. / Verstoring van de pilcyclus tijdens het gelijktijdig gebruik van itraconazol en orale anticonceptiva.
Ned Tijdschr Geneeskd
; 142(3): 146-9, 1998 Jan 17.
Article
de Nl
| MEDLINE
| ID: mdl-9557015
ABSTRACT
Since the introduction of itraconazole in the Netherlands, the Netherlands Pharmacovigilance Foundation LAREB and the Inspectorate for Health Care received 15 reports of pill cycle disturbances and one of pregnancy occurring during simultaneous use of itraconazole and oral contraceptives. Twelve women used oral contraceptives containing ethinylestradiol and desogestrel. In these women, the withdrawal bleeding was either delayed or did not occur at all; one of these women reported a transiently positive pregnancy test after previous breakthrough bleedings. Three women who used a contraceptive containing ethinylestradiol and levonorgestrel had a breakthrough bleeding. One woman who used an oral contraceptive containing ethinylestradiol and cyproterone acetate became pregnant during the concomitant use of itraconazole. The possible mechanism involved remains to be explained. Although an influence of itraconazole on the reliability of oral contraceptives is uncertain, additional contraceptive measurements might be considered.
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Collection:
01-internacional
Base de données:
MEDLINE
Sujet principal:
Itraconazole
/
Contraceptifs oraux combinés
/
Antifongiques
Limites:
Adult
/
Female
/
Humans
/
Middle aged
/
Pregnancy
Langue:
Nl
Journal:
Ned Tijdschr Geneeskd
Année:
1998
Type de document:
Article